by Dr. Madalene Heng MD, FRACP, FACD, FAAD
Without the Use of Immunosuppressants

Phosphorylase kinase (ph-K) is a unique enzyme released within 5 minutes following skin injury, and serves as a catalyst for the processes that result in the subsequent activation of over 200 genes responsible for inflammation, cell damage and scarring. In the case of Psoriasis, due to a genetic inability to "switch off" phosphorylase kinase activity, the psoriatic patient continues to exhibit continual cell proliferation which results in symptoms such as flaking, plaque development, lesions which do not heal, and a compromised skin barrier.

The usual treatment of immunosuppressants and/or steroids (both oral and topical) does not suppress phosphorylase kinase by itself, and does not kill off the Ki-67+ epidermal cells that cause the skin to grow rapidly, as in the case of psoriasis. The disease often recurs when treatment is stopped. In addition, there may be unwanted side effects. In this website, we detail my standard regimen of treatment as an alternative without the use of immunosuppressants. 

My patients usually are 65-70% improved in 4 weeks, 85% improved in 8 weeks, 95% in 3 months, and almost totally clear in 4-6 months. The palms and soles take longer because they have 200 layers of stratum corneum instead of 10 layers of stratum corneum to replace. It takes 60 days to replace the first layer of stratum corneum. 

As long as the precipitating factors are treated and removed, it is my experience that if patients use the protocol in this website correctly, and are treated until the Ki-67+ cells are normalized, the disease does not recur after the treatment is tapered off. 

These are my suggested methods of treatment based on over 35 years of research and practice. See your doctor before applying any psoriasis treatment methods. Please let me know if I may be of further help. 

For questions about my regimen, please fill out the contact form:

-Madalene C.Y. Heng MD, FRACP, FACD, FAAD
Clinical Professor of Medicine, Dermatology
David Geffen School of Medicine, UCLA